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Since MAS can have variedpathophysiologic mechanisms of which surfac-tant de?ciency is only one, an approach may beto judge the lung volume clinically or radiologi-cally and use surfactant if the picture is like RDS.In the developing world, use of SRT for MASmay be a very expensive proposition in view ofthe bigger weight of these babies and the need formultiple doses.
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In these procedures, thereaction product ofthe enzyme activity, rather than theenzymeitself, isvisualized.
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